What does acquaint mean? acquaint. Verb 1. (transitive, followed by with) ; To furnish or give experimental knowledge of; to make (one) ; to know; to make familiar. 2. (transitive, archaic, followed by of or that) ; To communicate notice to; to inform; to make cognizant. 3. (transitive, obsolete) ; To familiarize; to accustom. For example, (Can we find and add a quotation of Evelyn to this entry?) acquaint. Adjective 1. (obsolete) ; Acquainted.